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Article

Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.

Circulation research - 18 Feb 2005

Phillips Helen M, Murdoch Jennifer N, Chaudhry Bill, Copp Andrew J, Henderson Deborah J

Abstract excerpt

Loop-tail (Lp) mice develop double outlet right ventricle and aortic arch defects, and the defects are caused by mutations in the Vangl2 gene. Vangl2 mRNA is found in the outflow tract myocardium, including the myocardializing cells that migrate into the outflow tract cushions. Analysis of muscul...

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Source

Identifiers

PMID: 15637299
DOI: 10.1161/01.RES.0000154912.08695.88

Genes

ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15637299-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.PMID 15637299Read ↗

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