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Article

Epithelial Properties of the Second Heart Field

4 Jan 2018

Abstract excerpt

The vertebrate heart tube forms from epithelial progenitor cells in the early embryo and subsequently elongates by progressive addition of second heart field (SHF) progenitor cells from adjacent splanchnic mesoderm. Failure to maximally elongate the heart results in a spectrum of morphological defects affecting the cardiac poles, including outflow tract alignment and atrioventricular septal defects, among the...

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Identifiers

PMID: 29301846
DOI: 10.1161/circresaha.117.310838

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