Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis.

doi:10.1016/j.bbrc.2008.10.114

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Article

Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis.

Biochemical and biophysical research communications - 19 Dec 2008

Murphy Lynea A, Sarge Kevin D

Abstract excerpt

Condensin is a 5 subunit complex that plays an important role in the structure of chromosomes during mitosis. It is known that phosphorylation of condensin subunits by cdc2/cyclin B at the beginning of mitosis is important for condensin activity, but the sites of these phosphorylation events have not been identified nor has their role in regulating condensin function. Here we identify two threonine residues in...

Topics

Adenosine Triphosphatases
Alanine
Amino Acid Sequence
Animals
CDC2 Protein Kinase
Cell Cycle Proteins
Chromosomes, Human
Cyclin B
DNA
DNA-Binding Proteins
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mitosis

Molecular Sequence Data

Multiprotein Complexes

Mutation

Phosphorylation

Threonine

Source

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Identifiers

PMID: 18977199
DOI: 10.1016/j.bbrc.2008.10.114
PMCID: PMC2633222

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