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Article

Structural basis of HEAT‐kleisin interactions in the human condensin I subcomplex

11 Mar 2019

Abstract excerpt

Abstract Condensin I is a multi‐protein complex that plays an essential role in mitotic chromosome assembly and segregation in eukaryotes. It is composed of five subunits: two SMC (SMC2 and SMC4), a kleisin (CAP‐H), and two HEAT‐repeat (CAP‐D2 and CAP‐G) subunits. Although balancing acts of the two HEAT‐repeat subunits have been demonstrated to enable this complex to support the dynamic assembly of chromosomal...

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PMID: 30858338
DOI: 10.15252/embr.201847183

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