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Article

The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes

17 Dec 2014

Abstract excerpt

How cell fate (survival or death) is determined and whether such determination depends on the strength of stimulation has remained unclear. In this study, we discover that the cell fate of cardiomyocytes switches from survival to death with the increase of β-adrenergic receptor (β-AR) stimulation. Mathematical simulations combined with biochemical experimentation of β-AR signalling pathways show that the gradual...

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PMID: 25517116
DOI: 10.1038/ncomms6777

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