Article

Dynamical analysis of a model of BCL-2-dependent cellular decision making

2025-07-11

Abstract excerpt

The BCL-2 protein family governs critical cell-fate decisions between survival, senescence, and apoptosis, yet the dynamical principles underlying these choices remain poorly understood. Here, we integrate mathematical modeling, bifurcation analysis, and stochastic simulations to dissect how BCL-2 network architecture encodes multistability and fate plasticity. Our coarse-grained model reveals tristable regimes re...

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Literature Corpus work: f1f432d4-b549-5107-8ca4-fc6663df2bd7
DOI: 10.1101/2025.07.08.663634

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