Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BAX and SMAC regulate bistable properties of the apoptotic caspase system

8 Feb 2021

Abstract excerpt

The initiation of apoptosis is a core mechanism in cellular biology by which organisms control the removal of damaged or unnecessary cells. The irreversible activation of caspases is essential for apoptosis, and mathematical models have demonstrated that the process is tightly regulated by positive feedback and a bistable switch. BAX and SMAC are often dysregulated in diseases such as cancer or neurodegeneration...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to CRISPR and Genetic Engineering
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33558564
DOI: 10.1038/s41598-021-82215-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BAX and SMAC regulate bistable properties of the apoptotic caspase systemPMID 33558564Read ↗

BAX and SMAC Regulate Bistable Properties of the Apoptotic Caspase SystemSemantic proximity Read ↗

Dynamical analysis of a model of BCL-2-dependent cellular decision makingSemantic proximity Read ↗

A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosisSemantic proximity Read ↗

Analysis of a mathematical model of apoptosis: individual differences and malfunction in programmed cell death.Semantic proximity Read ↗

Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death.Semantic proximity Read ↗

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cellsSemantic proximity Read ↗

Cross-Talk in Cell Death SignalingSemantic proximity Read ↗

Unraveling the intracellular cross-talk governing the balance between TNF <i>α</i> mediated survival and apoptosis signalingSemantic proximity Read ↗

The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancerSemantic proximity Read ↗

Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.Semantic proximity Read ↗

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Semantic proximity Read ↗

Bcl-xL controls a switch between cell death modes during mitotic arrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.