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Article

Mathematical modeling physiological effects of the overexpression of β2-adrenoceptors in mouse ventricular myocytes.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2018

Rozier Kelvin, Bondarenko Vladimir E

Abstract excerpt

Transgenic (TG) mice overexpressing β2-adrenergic receptors (β2-ARs) demonstrate enhanced myocardial function, which manifests in increased basal adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo. To gain insights into the mechanisms of these effects, we developed a comprehensive mathematical model of the mouse ventricular myocyte overexpressing β2-ARs. We...

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Identifiers

PMID: 29101164
DOI: 10.1152/ajpheart.00160.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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