Article

BAX and SMAC Regulate Bistable Properties of the Apoptotic Caspase System

2019-12-06

Abstract excerpt

The initiation of apoptosis is a core mechanism in cellular biology by which organisms control the removal of damaged or unnecessary cells. The irreversible activation of caspases is essential for apoptosis, and mathematical models have demonstrated that the process is tightly regulated by positive feedback and a bistable switch. BAX and SMAC are often dysregulated in diseases such as cancer or neurodegeneration a...

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Literature Corpus work: b3e0008f-6dbb-57b1-8048-c4421b57fb2a
DOI: 10.1101/867663

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