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Article

The binary switch between life and death of endoplasmic reticulum-stressed β cells

1 Apr 2010

Abstract excerpt

PURPOSE OF REVIEW: beta-Cell death is an important pathogenic component of both type 1 and type 2 diabetes. However, the specific molecular pathways and interactions involved in this process are not completely understood. Increasing evidence indicates that a type of cell stress called endoplasmic reticulum stress (ER stress) plays an important role in beta-cell death. In the present article, we discuss a...

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PMID: 20125004
DOI: 10.1097/med.0b013e3283372843

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