Article
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy.
Molecular psychiatry - 1 Jan 2014
Reif A, Richter J, Straube B, Höfler M, Lueken U, Gloster A T, Weber H, Domschke K, Fehm L, Ströhle A, Jansen A, Gerlach A, Pyka M, Reinhardt I, Konrad C, Wittmann A, Pfleiderer B, Alpers G W, Pauli P, Lang T, Arolt V, Wittchen H-U, Hamm A, Kircher T, Deckert J
Abstract excerpt
Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoamine oxidase A (MAOA) is noteworthy given that genetic variation has been demonstrated to influence gene expression and monoamine levels. Long alleles of the MAOA-uVNTR promoter polymorphism are associated...
Topics
- Agoraphobia
- Brain
- Cognitive Behavioral Therapy
- Conditioning, Classical
- Electrocardiography
- Female
- Follow-Up Studies
- Gene Frequency
- Genotype
- Humans