Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.

doi:10.1016/j.nicl.2019.102029

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Article

Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.

NeuroImage. Clinical - 1 Jan 2019

Gechter Johanna, Liebscher Carolin, Geiger Maximilian J, Wittmann André, Schlagenhauf Florian, Lueken Ulrike, Wittchen Hans-Ulrich, Pfleiderer Bettina, Arolt Volker, Kircher Tilo, Straube Benjamin, Deckert Jürgen, Weber Heike, Herrmann Martin J, Reif Andreas, Domschke Katharina, Ströhle Andreas

Abstract excerpt

INTRODUCTION: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural "fear network". We aimed to investigate whether the NPSR1 T risk...

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PMID: 31734525
DOI: 10.1016/j.nicl.2019.102029
PMCID: PMC6854061

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