Article
Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter.
PloS one - 1 Jan 2013
Heitland Ivo, Groenink Lucianne, Bijlsma Elisabeth Y, Oosting Ronald S, Baas Johanna M P
Abstract excerpt
The ability to identify predictors of aversive events allows organisms to appropriately respond to these events, and failure to acquire these fear contingencies can lead to maladaptive contextual anxiety. Recently, preclinical studies demonstrated that the corticotropin-releasing factor and serotonin systems are interactively involved in adaptive fear acquisition. Here, 150 healthy medication-free human subjects...
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