Article
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.
Molecular psychiatry - 1 Oct 2017
Deckert J, Weber H, Villmann C, Lonsdorf T B, Richter J, Andreatta M, Arias-Vasquez A, Hommers L, Kent L, Schartner C, Cichon S, Wolf C, Schaefer N, von Collenberg C R, Wachter B, Blum R, Schümann D, Scharfenort R, Schumacher J, Forstner A J, Baumann C, Schiele M A, Notzon S, Zwanzger P, Janzing J G E, Galesloot T, Kiemeney L A, Gajewska A, Glotzbach-Schoon E, Mühlberger A, Alpers G, Fydrich T, Fehm L, Gerlach A L, Kircher T, Lang T, Ströhle A, Arolt V, Wittchen H-U, Kalisch R, Büchel C, Hamm A, Nöthen M M, Romanos M, Domschke K, Pauli P, Reif A
Abstract excerpt
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide...
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