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Article

Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.

Journal of neurochemistry - 1 Dec 2014

Rutherford Nicola J, Moore Brenda D, Golde Todd E, Giasson Benoit I

Abstract excerpt

The discoveries of mutations in SNCA were seminal findings that resulted in the knowledge that α-synuclein (αS) is the major component of Parkinson's disease-associated Lewy bodies. Since the pathologic roles of these protein inclusions and SNCA mutations are not completely established, we characterized the aggregation properties of the recently identified SNCA mutations, H50Q and G51D, to provide novel insights....

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Identifiers

PMID: 24984882
DOI: 10.1111/jnc.12806

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.PMID 24984882Read ↗

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