Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host genetics predict clinical deterioration in HCV-related cirrhosis.

PloS one - 1 Jan 2014

King Lindsay Y, Johnson Kara B, Zheng Hui, Wei Lan, Gudewicz Thomas, Hoshida Yujin, Corey Kathleen E, Ajayi Tokunbo, Ufere Nneka, Baumert Thomas F, Chan Andrew T, Tanabe Kenneth K, Fuchs Bryan C, Chung Raymond T

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to PNPLA3 gene
Share to Genotyping Techniques
Share to Hepatitis C, Chronic
Share to Kaplan-Meier Estimate
Share to Liver Cirrhosis
Share to Polymorphism, Single Nucleotide
Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25504078
DOI: 10.1371/journal.pone.0114747
PMCID: PMC4264769

Genes

EGF
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host genetics predict clinical deterioration in HCV-related cirrhosis.PMID 25504078Read ↗

Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.Semantic proximity Read ↗

Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens.Semantic proximity Read ↗

A Variant in PNPLA3 Associated With Fibrosis Progression but not Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection.Semantic proximity Read ↗

Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.Semantic proximity Read ↗

Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection.Semantic proximity Read ↗

Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patientsSemantic proximity Read ↗

PNPLA3 risk allele is associated with risk of hepatocellular carcinoma but not decompensation in compensated cirrhosis.Semantic proximity Read ↗

PNPLA3 and IL 28B signature for predicting susceptibility to chronic hepatitis C infection and fibrosis progression.Semantic proximity Read ↗

The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients.Semantic proximity Read ↗

Linked Intronic Polymorphisms of the PNPLA3 Gene Are Associated with Serum Markers of Liver Injury in Patients with Spontaneous HCV Clearance.Semantic proximity Read ↗

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.Semantic proximity Read ↗

Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.