Article
The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2015
Brouwer Willem P, van der Meer Adriaan J, Boonstra Andre, Pas Suzan D, de Knegt Robert J, de Man Rob A, Hansen Bettina E, ten Kate Fiebo J W, Janssen Harry L A
Abstract excerpt
BACKGROUND & AIMS: We aimed to assess the association between the patatin-like phospholipase domain-containing-3 (PNPLA3) I148M polymorphism, liver histology and long-term outcome in chronic hepatitis B (CHB) patients. METHODS: We enrolled 531 consecutive treatment naïve CHB patients diagnosed from 1985 to 2012 with an available liver biopsy for reassessment, and sample for genetic testing. Data on all-cause...
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