Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.

doi:10.1002/hep.24350

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Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.

Hepatology (Baltimore, Md.) - 1 Jul 2011

Trépo Eric, Pradat Pierre, Potthoff Andrej, Momozawa Yukihide, Quertinmont Eric, Gustot Thierry, Lemmers Arnaud, Berthillon Pascale, Amininejad Leila, Chevallier Michéle, Schlué Jerome, Kreipe Hans, Devière Jacques, Manns Michael, Trépo Christian, Sninsky John, Wedemeyer Heiner, Franchimont Denis, Moreno Christophe

Abstract excerpt

UNLABELLED: Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis in nonalcoholic fatty liver disease. The aim of...

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PMID: 21488075
DOI: 10.1002/hep.24350

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PNPLA3

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