Article
Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens.
PloS one - 1 Jan 2015
Tamaki Nobuharu, Kurosaki Masayuki, Higuchi Mayu, Takada Hitomi, Nakakuki Natsuko, Yasui Yutaka, Suzuki Shoko, Tsuchiya Kaoru, Nakanishi Hiroyuki, Itakura Jun, Takahashi Yuka, Ogawa Shintaro, Tanaka Yasuhito, Asahina Yasuhiro, Izumi Namiki
Abstract excerpt
The assessment of individual risk of fibrosis progression in patients with chronic hepatitis C is an unmet clinical need. Recent genome-wide association studies have highlighted several genetic alterations as predictive risk factors of rapid fibrosis progression in chronic hepatitis C. However, most of these results require verification, and whether the combined use of these genetic predictors can assess the risk...
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