Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linked Intronic Polymorphisms of the PNPLA3 Gene Are Associated with Serum Markers of Liver Injury in Patients with Spontaneous HCV Clearance.

International journal of molecular sciences - 2 Jan 2026

Gonzalez-Aldaco Karina, Torres-Reyes Luis A, Panduro Arturo, Roman Sonia

Abstract excerpt

Genetic variation in PNPLA3 influences liver fat accumulation and hepatocellular injury in various liver diseases. However, the role of PNPLA3 intronic polymorphisms in hepatic damage among hepatitis C virus (HCV) patients remains unclear. This study aims to investigate the association of three intronic PNPLA3 polymorphisms (rs4823173, rs2896019, and rs2281135) with liver injury in HCV-infected patients with...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Hepacivirus
Share to Hepatitis C, Chronic
Share to Introns
Share to Linkage Disequilibrium
Share to Lipase
Share to Liver
Share to Phospholipases A2, Calcium-Independent

Source

Open in PubMed Open full text

Identifiers

PMID: 41516346
DOI: 10.3390/ijms27010473
PMCID: PMC12786674

Genes

PNPLA3
AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linked Intronic Polymorphisms of the PNPLA3 Gene Are Associated with Serum Markers of Liver Injury in Patients with Spontaneous HCV Clearance.PMID 41516346Read ↗

The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.Semantic proximity Read ↗

Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B.Semantic proximity Read ↗

PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism.Semantic proximity Read ↗

A Variant in PNPLA3 Associated With Fibrosis Progression but not Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection.Semantic proximity Read ↗

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.Semantic proximity Read ↗

PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.Semantic proximity Read ↗

Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens.Semantic proximity Read ↗

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.Semantic proximity Read ↗

The impact of the PNPLA3 rs738406 C>G polymorphism on hepatocellular carcinoma risk in Brazilian patients with chronic hepatitis C and advanced fibrosis.Semantic proximity Read ↗

PNPLA3 rs738409 C>G Variant Predicts Fibrosis Progression by Noninvasive Tools in Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.Semantic proximity Read ↗

PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.