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Article

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Schneider Benoît, Mutel Vincent, Pietri Mathéa, Ermonval Myriam, Mouillet-Richard Sophie, Kellermann Odile

Abstract excerpt

Putative functions of the cellular prion protein, PrPC, include resistance to oxidative stress, copper uptake, cell adhesion, and cell signaling. Here, we report NADPH oxidase-dependent reactive oxygen species (ROS) production and extracellular regulated kinases 1/2 (ERK1/2) phosphorylation on PrPC stimulation in the 1C11 neuroectodermal precursor, in its neuronal differentiated progenies, and in GT1-7...

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Identifiers

PMID: 14597699
DOI: 10.1073/pnas.2235648100
PMCID: PMC263804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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