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Article

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.

Journal of neuroinflammation - 26 Jul 2010

Dohi Kenji, Ohtaki Hirokazu, Nakamachi Tomoya, Yofu Sachiko, Satoh Kazue, Miyamoto Kazuyuki, Song Dandan, Tsunawaki Shohko, Shioda Seiji, Aruga Tohru

Abstract excerpt

BACKGROUND: We hypothesized that gp91phox (NOX2), a subunit of NADPH oxidase, generates superoxide anion (O2-) and has a major causative role in traumatic brain injury (TBI). To evaluate the functional role of gp91phox and reactive oxygen species (ROS) on TBI, we carried out controlled cortical impact in gp91phox knockout mice (gp91phox-/-). We also used a microglial cell line to determine the activated cell...

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Identifiers

PMID: 20659322
DOI: 10.1186/1742-2094-7-41
PMCID: PMC2917406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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