Article
Preliminary characterization of cis interactions between mutations of poliovirus genome.
Research in virology - 1 Jan 2000
Agut H, Kean K M, Fichot O, Girard M
Abstract excerpt
The effects of three distinct point mutations in the P3 genomic region of poliovirus type 1 (Mahoney strain) have previously been analysed. A U to C change at position 5658, which modifies the proteinase 3C, is responsible for a small plaque phenotype and defective RNA replication. An A to G change at position 7256, which modifies the replicase 3D, is responsible for temperature sensitivity. A C to U change at...
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