Article
High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1992
de la Torre J C, Giachetti C, Semler B L, Holland J J
Abstract excerpt
We employed independent clones of a temperature-sensitive mutant of type 1 poliovirus, 3AB-310/4, to quantitate the frequency of specific U----C transitions at nucleotide 5310, within the genomic region encoding polypeptide 3AB, which is involved in the initiation of RNA replication. Only this U----C base substitution restores the wild-type phenotypic ability to form plaques at 39 degrees C; the other two base...
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