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Article

Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5' noncoding region.

Journal of virology - 1 Feb 1990

Andino R, Rieckhof G E, Trono D, Baltimore D

Abstract excerpt

The poliovirus mutant 5NC-11 has a 4-base insertion at position 70 within the 5' untranslated region and is deficient in RNA synthesis. Revertants from 5NC-11 were isolated, showing a partial recovery of wild-type levels of RNA synthesis. The 5' noncoding region of those revertants contained the mutation intact; mix-and-match experiments with the cDNA from these revertants revealed that a restricted region within...

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Identifiers

PMID: 2153227
DOI: 10.1128/JVI.64.2.607-612.1990
PMCID: PMC249150

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