Article
Paramyxovirus mRNA editing leads to G deletions as well as insertions.
The EMBO journal - 15 Nov 1994
Jacques J P, Hausmann S, Kolakofsky D
Abstract excerpt
Paramyxoviruses are thought to edit their P gene mRNAs co-transcriptionally, by a mechanism in which the polymerase stutters and reads the same template base more than once. Sendai virus (SeV) and bovine parainfluenza virus type 3 (bPIV3) are closely related viruses, but SeV edits its P gene mRNA with the insertion of a single G residue (at approximately 50% frequency) within the sequence 5' A6G3, whereas bPIV3...
Topics
- Base Sequence
- DNA, Complementary
- DNA-Directed RNA Polymerases
- Gene Expression Regulation, Viral
- Genes, Viral
- Genetic Vectors
- Guanine
- HeLa Cells
- Humans
- Models, Genetic
- Molecular Sequence Data