Article
Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2015
Tanaka Aki, Akimoto Yusuke, Kobayashi Satoko, Hisatake Koji, Hanaoka Fumio, Ohkuma Yoshiaki
Abstract excerpt
In eukaryotes, the general transcription factor TFIIE consists of two subunits, α and β, and plays essential roles in transcription. Structure-function studies indicate that TFIIE has three-winged helix (WH) motifs, with one in TFIIEα and two in TFIIEβ. Recent studies suggested that, by binding to the clamp region of RNA polymerase II, TFIIEα-WH promotes the conformational change that transforms the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.