Article
Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Murakami Kenji, Gibbons Brian J, Davis Ralph E, Nagai Shigeki, Liu Xin, Robinson Philip J J, Wu Tinghe, Kaplan Craig D, Kornberg Roger D
Abstract excerpt
General transcription factor TFIIH, previously described as a 10-subunit complex, is essential for transcription and DNA repair. An eleventh subunit now identified, termed Tfb6, exhibits 45% sequence similarity to human nuclear mRNA export factor 5. Tfb6 dissociates from TFIIH as a heterodimer with the Ssl2 subunit, a DNA helicase that drives promoter melting for the initiation of transcription. Tfb6 does not,...
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