Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH.

Abstract excerpt

TFIIH is a 10-subunit RNA polymerase II basal transcription factor with a dual role in DNA repair. TFIIH contains three enzymatic functions and over 30 conserved subdomains and topological regions. We systematically tested the function of these regions in three TFIIH core module subunits, i.e., Ssl1, Tfb4, and Tfb2, in the DNA translocase subunit Ssl2, and in the kinase module subunit Tfb3. Our results are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Helicases
• Share to Mutation
• Share to Protein Binding