Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A debilitating mutation in transcription factor IIE with differential effects on gene expression in yeast.

The Journal of biological chemistry - 9 Jan 1998

Tijerina P, Sayre M H

Abstract excerpt

The influence of transcription factor (TF) IIE on mRNA synthesis in vivo was examined in a temperature-sensitive yeast mutant. A missense mutation in the conserved zinc finger domain severely weakened TFIIE's transcription activity without appreciably affecting its quaternary structure, chromatographic properties, or cellular abundance. The mutation conferred recessive slow-growth and heat-sensitive phenotypes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Fungal
Share to Hot Temperature
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to RNA, Messenger

Share to Saccharomyces cerevisiae

Share to Transcription Factors

Share to Transcription, Genetic

Source

Identifiers

PMID: 9422776
DOI: 10.1074/jbc.273.2.1107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A debilitating mutation in transcription factor IIE with differential effects on gene expression in yeast.PMID 9422776Read ↗

Transcription-coupled DNA repair in yeast transcription factor IIE (TFIIE) mutants.Semantic proximity Read ↗

Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly.Semantic proximity Read ↗

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo.Semantic proximity Read ↗

Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions.Semantic proximity Read ↗

Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.Semantic proximity Read ↗

The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains.Semantic proximity Read ↗

Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

TFIIS is required for reproductive development and thermal adaptation in barley.Semantic proximity Read ↗

Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors.Semantic proximity Read ↗

Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.