Article
The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2015
Etheridge Timothy, Rahman Mizanur, Gaffney Christopher J, Shaw Debra, Shephard Freya, Magudia Jignesh, Solomon Deepak E, Milne Thomas, Blawzdziewicz Jerzy, Constantin-Teodosiu Dumitru, Greenhaff Paul L, Vanapalli Siva A, Szewczyk Nathaniel J
Abstract excerpt
The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal muscle morphology. However, the importance of the entire adhesome for muscle structure and function is unknown. We used RNA interference to knock down 113 putative...
Topics
- Adenosine Triphosphate
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Knockdown Techniques
- Genes, Helminth
- Integrins
- Mechanotransduction, Cellular