Article

Mechanotransduction coordinates extracellular matrix protein homeostasis promoting longevity in <i>C. elegans</i>

2022-08-30

Abstract excerpt

Although it is postulated that dysfunctional extracellular matrices (ECM) drive aging and disease, how ECM integrity assures longevity is unknown. Here, using proteomics and in-vivo monitoring of fluorescently tagged ECM proteins, we systematically examined the ECM composition during Caenorhabditis elegans aging revealing three distinct collagen dynamics. We show that age-dependent stiffening of inert collagen w...

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Literature Corpus work: b582de82-b0b5-5c5e-926f-613d28874545
DOI: 10.1101/2022.08.30.505802

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