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Article

LKB1 Deficiency Sensitizes Mice to Carcinogen-Induced Tumorigenesis

1 Jan 2008

Abstract excerpt

Lkb1 is a central regulator of cell polarity and energy metabolism through its capacity to activate the AMP-activated protein kinase (AMPK)-related family of protein kinases. Germ line-inactivating mutation of Lkb1 leads to Peutz-Jeghers syndrome, which is characterized by benign hamartomas and a susceptibility to malignant epithelial tumors. Mutations in Lkb1 are also found in sporadic carcinomas, most...

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PMID: 18172296
DOI: 10.1158/0008-5472.can-07-3225

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