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Article

LKB1 Is Recruited to the p21/WAF1 Promoter by p53 to Mediate Transcriptional Activation

15 Nov 2006

Abstract excerpt

The tumor suppressor LKB1 is an evolutionarily conserved serine/threonine kinase. In humans, LKB1 can be inactivated either by germ-line mutations resulting in Peutz-Jeghers syndrome or by somatic mutations causing predisposition to multiple sporadic cancers. LKB1 has wide-ranging functions involved in tumor suppression and cell homeostasis, including establishing cell polarity, setting energy metabolic balance...

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PMID: 17108107
DOI: 10.1158/0008-5472.can-06-0999

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