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Article

Molecular mechanisms of tumor suppression by LKB1.

FEBS letters - 6 Apr 2011

Vaahtomeri Kari, Mäkelä Tomi P

Abstract excerpt

The LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and cervical cancers and germline mutations are causative for Peutz-Jeghers syndrome characterized by gastrointestinal polyposis. The intracellular LKB1 kinase is implicated in regulating polarity, metabolism, cell differentiation, and proliferation - all functions potentially contributing to tumor suppression. LKB1 acts as an...

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Identifiers

PMID: 21192934
DOI: 10.1016/j.febslet.2010.12.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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