Article
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
The Biochemical journal - 1 Dec 2002
Sapkota Gopal P, Deak Maria, Kieloch Agnieszka, Morrice Nick, Goodarzi Aaron A, Smythe Carl, Shiloh Yosef, Lees-Miller Susan P, Alessi Dario R
Abstract excerpt
The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz-Jeghers cancer syndrome. We previously found that LKB1 was phosphorylated at Thr-366 in vivo, a residue conserved in mammalian, Xenopus and Drosophila LKB1, located on a C-terminal non-catalytic moiety of the enzyme. Mutation of Thr-366 to Ala or Asp partially inhibited the ability...
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