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Article

Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma.

The Journal of allergy and clinical immunology - 1 May 2015

Lo Chun-Yu, Michaeloudes Charalambos, Bhavsar Pankaj K, Huang Chien-Da, Wang Chun-Hua, Kuo Han-Pin, Chung Kian Fan

Abstract excerpt

BACKGROUND: Patients with severe asthma are less responsive to corticosteroid therapy and show increased airway remodeling. The mesenchymal progenitors, fibrocytes, may be involved in the remodeling of asthmatic airways. We propose that fibrocytes in severe asthma are different from those in nonsevere asthma. OBJECTIVES: To examine the survival, myofibroblastic differentiation, and C-C chemokine receptor 7 (CCR7)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25488691
DOI: 10.1016/j.jaci.2014.10.031

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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