Article
Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis.
PloS one - 1 Jan 2013
Huaux François, Noel Sabrina, Dhooghe Barbara, Panin Nadtha, Lo Re Sandra, Lison Dominique, Wallemacq Pierre, Marbaix Etienne, Scholte Bob J, Lebecque Patrick, Leal Teresinha
Abstract excerpt
Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown. We evaluated inflammatory and fibrosis responses to bleomycin in F508del homozygous and wild-type mice, and phenotype of fibroblasts explanted from mouse lungs and skin. The effect of vardenafil, a...
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