Article
Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle.
The Journal of allergy and clinical immunology - 1 Mar 2017
Austin Philip J, Tsitsiou Eleni, Boardman Charlotte, Jones Simon W, Lindsay Mark A, Adcock Ian M, Chung Kian Fan, Perry Mark M
Abstract excerpt
BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas changed expression has been observed in CD8 T cells from patients with severe asthma. METHODS: Primary ASMCs were...
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