Article

Investigation of corticosteroid responsiveness in airway smooth muscle cells of severe asthma

2013-01-01

Abstract excerpt

Asthma is characterised by airway inflammation, hyper-responsiveness and airway remodelling. Features of airway remodelling include hypertrophy/hyperplasia of airway smooth muscle cells (ASMC), which possess an important synthetic capacity in addition to their contractile function. Patients with severe asthma respond poor to even high-dose corticosteroids and consume enormous healthcare resources. Corticosteroid i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f567bdfa-597a-5025-a756-b3b51d5adfbb
DOI: 10.25560/11590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of corticosteroid responsiveness in airway smooth muscle cells of severe asthmaDOI 10.25560/11590Read

Emerging roles of pulmonary macrophages in driving the development of severe asthmaSemantic proximity Read

Molecular mechanisms of corticosteroid actions in chronic inflammatory airway diseasesSemantic proximity Read

Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma.Semantic proximity Read

Emerging mediators of airway smooth muscle dysfunction in asthma.Semantic proximity Read

How corticosteroids control inflammation: Quintiles Prize Lecture 2005Semantic proximity Read

Association Between IL-1 β /TNF- α –Induced Glucocorticoid-Sensitive Changes in Multiple Gene Expression and Altered Responsiveness in Airway Smooth MuscleSemantic proximity Read

Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models.Semantic proximity Read

Beyond corticosteroids: future prospects in the management of inflammation in COPD.Semantic proximity Read

Addressing corticosteroid insensitivity in adults with asthma.Semantic proximity Read

Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle.Semantic proximity Read

Differences in the inflammatory response and corticoid responsiveness of human lung macrophages and parenchymal explants exposed to cigarette smoke extractsSemantic proximity Read

Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epitheliumSemantic proximity Read