Article
Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease.
Allergy - 1 Apr 2017
Wright A K A, Newby C, Hartley R A, Mistry V, Gupta S, Berair R, Roach K M, Saunders R, Thornton T, Shelley M, Edwards K, Barker B, Brightling C E
Abstract excerpt
BACKGROUND: The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilizing flow cytometry to identify circulating, collagen type 1+ cells, we found two populations: (i) CD45+ CD34+ (fibrocytes) and (ii) CD45+ CD34- [myeloid-derived...
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