Article
Monocyte-derived fibrocytes induce an inflammatory phenotype in airway smooth muscle cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2014
Lin T-Y, Venkatesan N, Nishioka M, Kyoh S, Al-Alwan L, Baglole C J, Eidelman D H, Ludwig M S, Hamid Q
Abstract excerpt
BACKGROUND: Infiltration of fibrocytes (FC) in the airway smooth muscle is a feature of asthma, but the pathological significance is unknown. OBJECTIVE: We sought to explore whether FC modulate the phenotype of airway smooth muscle cells (ASMC) in asthmatic vs. control subjects. METHODS: Fibrocytes were isolated from CD14+ monocytes from asthmatic and normal subjects. Proliferation of ASMC of asthmatic or normal...
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