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Article

Decreased Fibronectin Production Significantly Contributes to Dysregulated Repair of Asthmatic Epithelium

28 Jan 2010

Abstract excerpt

RATIONALE: Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro. OBJECTIVES: To determine whether dysregulated ECM production by the epithelium plays a role in aberrant repair in asthma. METHODS: Airway epithelial cells (AEC) from children with...

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PMID: 20110557
DOI: 10.1164/rccm.200907-1071oc

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