Article
Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.
Circulation - 18 Oct 2005
Dries Daniel L, Victor Ronald G, Rame J Eduardo, Cooper Richard S, Wu Xiaodong, Zhu Xiaofeng, Leonard David, Ho Su-Inn, Wu Qingyu, Post Wendy, Drazner Mark H
Abstract excerpt
BACKGROUND: The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes. METHOD AND RESULTS: This genotype-phenotype genetic association study included replication samples and genomic control to correct for population stratification....
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