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Article

Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2012

Wang Wei, Cui Yujie, Shen Jianzhong, Jiang Jingjing, Chen Shenghan, Peng Jianhao, Wu Qingyu

Abstract excerpt

Blacks represent a high-risk population for salt-sensitive hypertension and heart disease, but the underlying mechanism remains unclear. Corin is a cardiac protease that regulates blood pressure by activating natriuretic peptides. A corin gene variant (T555I/Q568P) was identified in blacks with hypertension and cardiac hypertrophy. In this study, we tested the hypothesis that the corin variant contributes to the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22987923
DOI: 10.1161/HYPERTENSIONAHA.112.201244
PMCID: PMC3475733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks.PMID 22987923Read ↗

Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload.Semantic proximity Read ↗

Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy.Semantic proximity Read ↗

A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity.Semantic proximity Read ↗

Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.Semantic proximity Read ↗

Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.Semantic proximity Read ↗

A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.Semantic proximity Read ↗

Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner.Semantic proximity Read ↗

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Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults.Semantic proximity Read ↗

Associations between potentially functional CORIN SNPs and serum corin levels in the Chinese Han population.Semantic proximity Read ↗

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