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Article

Protein folding alterations in amyotrophic lateral sclerosis.

Brain research - 1 Oct 2016

Parakh Sonam, Atkin Julie D

Abstract excerpt

Protein misfolding leads to the formation of aggregated proteins and protein inclusions, which are associated with synaptic loss and neuronal death in neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that targets motor neurons in the brain, brainstem and spinal cord. Several proteins misfold and are associated either genetically or pathologically in ALS, including...

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Identifiers

PMID: 27064076
DOI: 10.1016/j.brainres.2016.04.010

Genes

SOD1
VCP

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