Unfolding the role of chaperones and chaperonins in human disease.

Abstract excerpt

Molecular chaperones comprise several highly conserved families of related proteins, many of which are also heat shock proteins. Chaperone proteins are crucial for the maintenance of native protein conformation and recent research has demonstrated several mechanisms where defective chaperone proteins have pathogenic consequences. In this article, we describe the structure and function of chaperones in bacterial...

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