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Article

Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.

Molecules (Basel, Switzerland) - 8 Oct 2010

Ali Yousuf O, Kitay Brandon M, Zhai R Grace

Abstract excerpt

Human neurodegenerative diseases arise from a wide array of genetic and environmental factors. Despite the diversity in etiology, many of these diseases are considered "conformational" in nature, characterized by the accumulation of pathological, misfolded proteins. These misfolded proteins can induce cellular stress by overloading the proteolytic machinery, ultimately resulting in the accumulation and deposition...

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Identifiers

PMID: 20938400
DOI: 10.3390/molecules15106859
PMCID: PMC3133442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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