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Article

Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Gallo Leandro H, Meyer April N, Motamedchaboki Khatereh, Nelson Katelyn N, Haas Martin, Donoghue Daniel J

Abstract excerpt

NFκB signaling plays a significant role in human disease, including breast and ovarian carcinoma, insulin resistance, embryonic lethality and liver degeneration, rheumatoid arthritis, aging and Multiple Myeloma (MM). Inhibitor of κB (IκB) kinase β (IKKβ) regulates canonical Nuclear Factor κB (NFκB) signaling in response to inflammation and cellular stresses. NFκB activation requires Lys63-linked (K63-linked)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25486864
DOI: 10.4161/15384101.2014.988026
PMCID: PMC4615003

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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