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Article

Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.

The Journal of biological chemistry - 30 Dec 2005

Carter Robert S, Pennington Kevin N, Arrate Pia, Oltz Eugene M, Ballard Dean W

Abstract excerpt

Transcription factor NF-kappaB governs the expression of multiple genes involved in cell growth, immunity, and inflammation. Nuclear translocation of NF-kappaB is regulated from the cytoplasm by IkappaB kinase-beta (IKKbeta), which earmarks inhibitors of NF-kappaB for polyubiquination and proteasome-mediated degradation. Activation of IKKbeta is contingent upon signal-induced phosphorylation of its T loop at...

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Identifiers

PMID: 16267042
DOI: 10.1074/jbc.M508656200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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